We recalled 82 punch biopsy (P-Bx) specimens taken from lesions suspicious for high-grade CIN under colposcopic examination before enrollment. ME-NBI was performed, and 30 E-Bx samples were taken from lesions suspicious for high-grade CIN and 15 from non-suspicious mucosa. Next to colposcopy, the same patients underwent ME-NBI just before conization. We prospectively enrolled 32 consecutive patients with confirmed or suspected high-grade CIN undergoing cervical conization. Here, we investigated the feasibility of targeted endoscopic forceps biopsy (E-Bx) under guidance of ME-NBI for the diagnosis of CIN.
We have developed flexible magnifying endoscopy with narrow band imaging (ME-NBI) for the diagnosis of CIN. The current standard for diagnosing cervical intraepithelial neoplasia (CIN) is colposcopy followed by punch biopsy.